Kidney Cancer Proves More Complicated Than Thought

kidney cancer proves more complicated than thought_The more scientists look, the more complex cancer seems to become. British scientists said on Wednesday they had found a batch of new gene mutations linked to kidney cancer, suggesting even this apparently “straightforward” cancer type can be divided into subtypes requiring tailored treatment.

Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, stands out from other cancers because it is remarkably consistent and the majority of cases are known to be driven by mutations in a single gene, called VHL.

Yet when researchers conducted a large DNA sequencing study of more than 3,500 genes from around 100 tumour samples, they found evidence that additional mutations in other genes were also driving cells to become cancerous.

Three of the genes were involved in modifying proteins called histones, which help package DNA into chromosomes and are critical to the functioning of cells, they reported in the journal Nature.

“Even in this clearest of cases, we see evidence for substantial genetic heterogeneity,” said Andy Futreal, co-leader of the Cancer Genome Project at the Wellcome Trust Sanger Institute in Cambridge.

While none of the new mutations accounted for more than 5 percent of cancer cases, the discovery should ultimately help in diagnosis and better selection of treatments for patients.

The latest findings underline the case for personalised medicine, or tailoring drugs to the genetic make-up of individual patients.

Scientists at the Sanger Institute last month also produced genetic “maps” identifying thousands of genetic mutations behind melanoma skin cancer and lung cancer.

Several personalised drugs are already used in cancer, including Roche’s Herceptin for breast cancer and AstraZeneca’s Iressa for lung cancer.

For drugmakers, tailored medicine is both an opportunity and a challenge as sub-dividing tumours by their molecular type shrinks the market for individual therapies.

Kidney cancer kills more than 100,000 people worldwide each year. Recent new drugs against the disease include Pfizer’s Sutent and Bayer’s Nexavar, which block cell proliferation and starve tumours of blood supply. By Ben Hirschler, The Guardian

Focal Point

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Obese Pregnant Women Should Gain Less Weight Than Currently Recommended

obese pregnant women_Saint Louis U. obstetrician criticizes new guidelines in medical journal Recent recommendations by the Institute of Medicine (IOM) call for women who are overweight or obese to gain more weight than they should, a Saint Louis University obstetrician wrote in a January commentary for Obstetrics & Gynecology.

Joined by several colleagues, Raul Artal, M.D., chair of the department of obstetrics, gynecology and women’s health at Saint Louis University, who has conducted extensive research on weight gain during pregnancy, did not endorse the IOM’s May 2009 recommendation. The IOM, a non-governmental, independent, nonprofit organization, provides advice that is designed to improve health to national decision makers and the public.

“The recently published IOM recommendations for gestational weight gain are virtually identical to those published in 1990 with one exception: obese women are now recommended to gain 11-20 pounds compared to the previous recommendations of at least 15 pounds,” Artal said.

“Recommending a single standard of weight gain for all obese classes is of concern since higher BMI levels are associated with more severe medical conditions and have long-term adverse health implications.”

Artal recommended obese women eat a nutrient-rich diet of between 2,000 and 2,500 calories a day, which would cause them to cap their weight gain at 10 pounds, and in some cases, lose weight.

Under a doctor’s guidance, he said, obese pregnant women can safely engage in physical activities and modify their diets to successfully limit their weight gain with no harmful effects on the fetus.

When obese women reduce the amount of weight they gain, they also cut their risk of developing complications such as gestational diabetes and preeclampsia. By contrast, obese women who gain too much weight increase their risk of developing these conditions who affect both mother and fetus.

Artal called excessive weight gain during pregnancy a significant contributor to the obesity epidemic.

“Excessive gestational weight gain has been implicated in an intergenerational vicious cycle of obesity as overweight and obese mothers give birth to big daughters who are more likely to become obese themselves and deliver large infants,” he said.

Pregnancy is an ideal time for women who are obese to exercise and watch what they eat, Artal said.

These lifestyle changes are safe and carry benefits that last long after they have given birth, Artal added.

“Similar to smoking cessation programs, pregnancy provides a unique and ideal opportunity for behavior modifications given high motivation and enhanced access to medical supervision,” he said.

“Limited weight gain in obese pregnant women has the added potential for setting the foundation for a healthier lifestyle over a woman’s lifespan.” redOrbit

Step Out In Style

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