A subclass of high-density lipoprotein (HDL) cholesterol, the so-called “good” cholesterol, may not protect against coronary heart disease (CHD) and in fact may be harmful, a new study has revealed.
The study by Harvard School of Public Health (HSPH) researchers is the first research to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective.
“This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavourable HDL with apoC-III,” said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study. [Read more...]





