Novel Way To Prevent Blindness Caused By Retinitis Pigmentosa

Scientists have discovered a novel way to use a radical new type of gene therapy to prevent blindness caused by retinitis pigmentosa.

The research, led by Muna Naash, at the University of Oklahoma Health Sciences Center, with collaborators in Cleveland and Buffalo, discovered a way to deliver known gene therapies directly to the light-sensitive cells affected by this disease.

The discovery already is being used to develop new treatments for another disease – macular degeneration, the leading cause of blindness in the United States.

“I am thrilled about it. That’s why we have been working so hard to get this as quickly as possible through the necessary experiments, so we can publish our findings and take it out to the patients,” Naash said.

“We hope the results of our study will be instrumental in generating a cure for the debilitating blindness associated with retinitis pigmentosa and other inherited and acquired retinal diseases. We want to give Oklahomans and others suffering from these diseases renewed independence and quality of life,” Naash added.

Utilizing nanoparticle technology, scientists created a microscopic capsule capable of carrying genetic therapies to their destination inside cells of the retina.

The tiny delivery vehicle is being tested with a variety of gene therapies in animal models with the potential of treating several diseases from bladder cancer to diabetes.

The capsules have proven very effective, carrying therapies to the designated location in the eye within 15 minutes of delivery and spreading the genetic repair message quickly to nearby cells.

Robert E. Leonard, an ophthalmologist at the Dean McGee Eye Institute, said: “This is an incredible breakthrough in terms of being able to treat with gene therapy. Outside of gene therapy, we are at a loss to be able to treat these patients, so this is incredibly important research.” DNA India

‘Majestic’ Forbidden City Wows Obama

obama at forbidden city_Anyone who has visited Beijing’s Forbidden City, the historic former home of China’s emperors during the Ming (1368-1644) and Qing (1644-1911) dynasties, knows even an entire day inside the massive architectural masterpiece is barely enough time to scratch the surface.

And for a president on a tight schedule, a whistle-stop tour of the landmark was always likely to be more of a photo opportunity than a learning experience.

But for United States President Barack Obama, a visit to the world-famous complex was not to be missed, no matter how limited his time.

Obama took a break from his diplomatic mission to Asia yesterday to spend 50 minutes inside the Forbidden City, which is also known as the Palace Museum.

Today, he will carve a little more me-time from his busy four-day agenda in China to visit the Great Wall before he leaves the country for the next leg of his tour in the Republic of Korea.

“It’s beautiful. It’s a magnificent place to visit. I will come back with my girls and my wife,” Obama said before leaving the museum through the northern Gate of Divine Prowess (Shenwu Men).

Fifty minutes earlier, Obama and Forbidden City curator Zheng Xinmiao had entered the palace through the main entrance on the south side – the Meridian Gate (Wu Men). The president had walked along the museum’s central axis, which is also the north-south line along which Beijing is orientated.

The Forbidden City was closed to the public for Obama’s visit.

In the bright sunshine and cool wind, without the usual hoards of visitors, the palace was a peaceful place. Its golden glazed rooftops still bore a dusting of snow that had fallen several days earlier.

Obama, who was dressed in a brown leather jacket and matching leather shoes spoke warmly about the palace.

“Very good!” he exclaimed in front of the Hall of Supreme Harmony (Taihe Dian) while standing before dozens of journalists and photographers. He also posed for photographs in the square in front of the hall.

Inside Taihe Dian, Zheng told Obama about the building’s history and its architecture and Obama asked about the words hanging on a board in the middle of the hall.

“Jian Ji Sui You,” he was told. It meant “emperors should make good rules”.

Taihe Dian was one of the largest wooden structures ever built in China and is the biggest hall in the Forbidden City.

At the Palace of Earthly Tranquility (Kunning Gong), Obama peered through the glass into the rooms that were used on the emperors’ wedding night.

“It is truly majestic, and a testimony to the greatness and longevity of Chinese civilization,” Obama wrote in the official guest book before leaving the museum.

Obama was the fourth incumbent US president to visit the Forbidden City, following in the footsteps of Richard Nixon, Gerald Ford and Bill Clinton.

Asked by reporters what he thought of the Forbidden City, Obama flashed his trademark smile. “Beautiful,” he said. After a slight pause he added, “spectacular”. By Lin Shujuan , China Daily

Hussain Sagar Lake Threatens Environment

hussain sagar lake_Rising pollution in the Hussain Sagar Lake is threatening the environmental in Hyderabad, Deccan.

Hussain Sagar Lake is the city’s main water body and a major tourist attraction. People are expressing serious concern over the worsening condition of the lake, which has become a health hazard for the people living in close proximity to the lake.

The immersion of idols made of toxic materials and usage of the lake by the nearby slums, the inter-connection of the sewage line and dumping of industrial and domestic wastes, are some of the reasons that are causing the lake to get polluted.

Those who pass by complain of the foul smell that comes from the lake and feel that the government should take steps to clean up the lake.

“It is very difficult to sit here for even five minutes, as the foul smell coming from the contaminated lake is very strong. This is a park where a common man comes for walking and jogging, but if there is no fresh oxygen then what is the use? The government should take action to clean the lake,” said Sunil a resident.

The environmentalists are also concerned over the health hazards caused by the pollution. They say appropriate methodology has to be opted for preventing the water contamination in the lake.

“The water from drains should be treated properly before it reaches the lake. Further, solid wastes should be taken care of and only clean and purified water should be injected into the lake. A treatment plant should be introduced to make the lake pollution free,” said Ved Kumar, an environmentalist.

He added that due to the pollution, the ground water will also get contaminated and the aquatic life will be severely affected.

Hussain sagar Lake is an artificial lake made in 1562 by the erstwhile Hyderabad Nizam for irrigation and drinking water purposes. The Siasat Daily

Pak Forces Close To Uprooting Taliban In Waziristan: Petraeus

pak forces close to uprooting taliban_Pakistani forces are close to uprooting Taliban and al-Qaeda sanctuaries in the country’s lawless area of south Waziristan, a top US General said on Saturday, but advised that the military needed to hold onto these captured territories.

Pakistan should put the cleared territories under a senior Corps Commander for post-conflict vigilance and rebuilding to ensure that these areas don’t slide back to become terrorist havens, General David Petraeus, Commander of the US Central Command, said.

Attributing the sudden rise in Taliban suicide attacks across Pakistan to the army striking decisive blows to their strongholds, the US commander said the military needed to continue their focus on the campaign.

“When you go into the enemy’s safe havens and sanctuaries, they come after you; and they try to open up new areas. It’s always been the case,” Patreaus said in an interview.

I think we have said that as Pakistan remains serious, and continues to build on the progress it achieved in Swat in NWFP. They have launched the operations into South Waziristan, as they have now, and are almost getting close to their final objectives, the enemy is going to fight back, he said.

While commending the strong military action taken by the Pakistani forces against terrorist groups inside the country, Petraeus said the situation there is still tough.

The US General, whose command stretches to US forces in Afghanistan, said the Pakistani military campaign in Waziristan, Swat and other rescue areas close to the Afghan frontier indicated that Islamabad had now come to realise that the existential threat to the country that is most pressing, at the very least, is the internal extremists, not necessarily India.

Not saying that that threat has gone away in their assessments, but the fact is, the threat that is most immediate — “the wolf closest to the sled,” as they say, indeed, was the internal extremists, Petraeus said.

“They have acted on that,” the US commander said.

Saying that the situation in Pakistan was “heartening” as compared to the critical situation there 10 months ago, Petraeus said.

The politicians including opposition leaders like Nawaz Sharif, the clergy and citizenry had now come to recognize that it was the internal militants that were threatening the very existence of Pakistan, he said.

But, he said, the need in the situation was “to hold and rebuild.”

“They have acted on that. Now, not only have they acted, they have done so with considerable skill. Pakistani military cleared and left Swat twice since 9/11. This time they cleared, and they have stayed. And they are holding and they are rebuilding.,” he noted. Indian Express

Filipino Boxer Pacquiao Sets Sights On Record Seventh Title

pacquiao_Manny Pacquiao will be looking to make history Saturday night when he takes on Miguel Cotto in a welterweight title fight at the MGM Grand in Las Vegas.

The 29-year-old Filipino superstar, who made a grand entrance along with his opponent at the scene of the fight Tuesday afternoon to begin final preparations, hopes to become the first boxer to win titles in seven weight divisions. He has held title belts from 112 pounds to 140 pounds.

Saturday’s bout (HBO pay-per-view, 9:30 p.m. ET) is considered a welterweight fight, even though it will be fought at a catch weight of 145 pounds, 2 pounds below the welterweight limit.

Cotto, however, has no intention of allowing himself to become Pacquiao’s seventh victim. It is Cotto’s WBO belt they’re fighting for, and the three-time champion, known for his powerful body punching, has held a title every year since 2004.

“If he thinks he is going to win seven titles in seven weight divisions now, he has picked the wrong moment, the wrong fighter and the wrong opponent,” Cotto said in a recent conference call. “If he thinks he is going to win the seventh title against Miguel Cotto, he is very wrong.”

Yet despite the fact that Cotto, also 29, from Puerto Rico, is a natural welterweight, and Pacquiao started his career in 1995 at 108 pounds, Pacquiao comes in as a heavy favorite. He’s listed at -350, meaning you need to place $350 to win $100.

Pacquiao (49-3-2, 37 KOs) is coming off a spectacular second-round knockout of Briton Ricky Hatton last May, while Cotto (34-1, 27 KOs) fought through a bad cut over his eye to win a split decision against African Joshua Clottey a month later.

The only loss of Cotto’s career came in a brutal beating at the hands of Antonio Margarito in July 2008. But there’s a cloud over Margarito’s victory since he was discovered before his next fight to have hardened plaster in his gloves, was subsequently KO’d by Shane Mosley, and then suspended from fighting in the USA for at least a year.

Cotto is undeterred by the odds against him.

“I don’t know anything about the betting business,” he said. “I am just here to try and bring my best every day … and I am working to beat Manny. If the people bet for Manny, it’s all right with me. All the people that are betting for Manny Pacquiao are not going to change the result of this fight.”

Pacquiao’s success against Mexican fighters has been well-documented. He was tagged as “The Mexican Assassin” after beating the best Mexican fighters of his era, including legends Erik Morales, Marco Antonio Barrera and Juan Manuel Marquez.

Cotto, however, says all that success means nothing against a fighter from Puerto Rico, which has its own proud boxing history, from world champions Wilfredo Benitez, Esteban DeJesus and Wilfredo Gomez to Carlos Ortiz and Felix “Tito” Trinidad.

“Different fighters and different styles, they had their moments with him,” Cotto said of Pacquiao’s Mexican opponents.

“It is going to be totally different with me. I have prepared myself for anything and everything that he brings. No matter who talks, or whoever says he is going to win, I know I am very confident that I am going to come out with a victory that night.” By Bob Velin, USA Today

US Officer Goes On Killing Spree At Army Base

us officer goes on killing spree at army base_Accustomed to terrible human loss overseas, the United States Army was last night struggling to come to terms with a savage outbreak of violence at home after an officer opened fire on the sprawling Fort Hood military base in Texas, which is at the tip of the spear of regular US troop deployments to Iraq and Afghanistan.

After hours of confusion when the entire complex – the largest such base in the world – located between Waco and Austin, was on a security lockdown, a military spokesman confirmed that the rampage had ended with the deaths of 12 people and the wounding of 31 others. Most of the injured had been rushed to hospitals across central Texas. The shock that was rippling across the country last night was hardly relieved after the shooter was identified as a trusted officer with medical duties. Officials said that Major Nadal Malik Hasan, a licensed doctor and psychiatrist, was shot and wounded by military police at the scene but not before he had extinguished the lives of 12 people. Military sources added that two other soldiers were apprehended after the slaughter, though by dusk last night one had been released. There was no information on what role the second may have had in the killings if any. Hasan opened fire, they said, with two handguns. There was no reason he should have been bearing arms as a doctor.

Major Hasan, said to be 39 years old, allegedly opened fire at roughly 1.30 pm, Texas time, inside a personnel processing building formally known as the Soldier Rating and Processing Center. It is a building soldiers routinely pass through while getting ready to deploy. However, at least one of the victims, was identified as a civilian.

A motive for the shooting was hard to pin down last night. However, there were reports that Hasan, who was trained also in psychiatry and medicine in Bethesda, Maryland, was preparing for deployment to Iraq and was not happy to be going there. He had previously worked at the Walter Reed veterans hospital outside Washington.

There have been six incidents on the ground in Iraq since the start of the conflict when US troops have been felled by one of their own with the loss of 14 lives. Last May, a soldier opened fire on fellow soldiers in a medical facility at Camp Liberty outside Baghdad killing five.

Lt General Bob Cone spoke to reporters on the perimeter of the base. “We have had a terrible tragedy at Fort Hood today. The situation is ongoing but we are very close to a resolution,” he said, almost three hours after the first shots were fired.

“The numbers that we are looking at are 12 dead and 31 wounded.” The wounded were being treated in hospitals across central Texas, he said.

The shooting will rekindle debate about the strains that have been placed for years on the US military community after eight years of conflict in Afghanistan and almost as many years in Iraq. For months, military leaders have been seeking ways to monitor the mental health of soldiers precisely to guard against such deadly tragedies. Fort Hood is home to a programme set up to help returning soldiers cope with stress incurred by warfare.

In Washington aides kept President Barack Obama abreast of developments at the huge complex that includes housing areas and several schools. Mr Obama called the shootings “horrifying”. Attending a conference on Native American rights, he added: “My immediate thoughts and prayers are with the wounded and with the families of those who have fallen… we will make sure we get answers to every single question about this horrible incident”.

For soldiers who are trained to face possible injury or worse while deployed abroad, there was no emotional preparation for the shock of such an indiscriminate act of mass killing taking place on US soil and indeed within the confines of one of their own bases where they would have considered themselves entirely safe.

“I am horrified just like everyone else,” Kay Bailey Hutchinson, a US Senator for Texas, said of the killings. “This is a base that has sent people time and time again to Iraq and now to Afghanistan. They have borne a lot of the responsibility for the war on terror and for this to happen at this particular base is heartbreaking.”

As many as 500 military personnel were mobilised at one stage to conduct a sweep of the base to ensure its security. Witnesses on the edge of the facility meanwhile saw ambulances coming and going from the main entrance and helicopters landing inside it to ferry the severely wounded to nearby hospitals.

Members of families were also assembled on parking lots on the edge of the base trying to determine whether any of their loved ones may have been hurt or killed in the shootings.

Fort Hood has close to 50,000 soldiers assigned to it. In addition, it is home to many military families. As well as sending solders into harm’s way in war zones – no other military base in the US has lost more men and women in Iraq than Fort Hood – it has seen many wounded soldiers returning from war.

Fort Hood: The world’s largest military base

* Fort Hood, near Austin, Texas, is the world’s largest military installation, occupying 340 square kilometres.

* It is home to more than 65,000 soldiers, civilian personnel and family members.

* Two armoured divisions are based there, and up to 40,000 US troops.

* It was opened in 1942, as a place to test anti-tank guns that were crucial to combating German blitzkrieg tactics.

* 75 troops at the base have committed suicide between the invasion of Iraq in 2003 and July this year – more than at any other army post.

* The base is home to III Corps, the official counteroffensive force, who are known as “America’s Hammer.”

* In January 2003, then President George W Bush addressed 4,500 troops at the base, and told them to be ready for war.

* The base’s Fourth Infantry Division captured Saddam Hussein in 2003.

By David Usborne, The Independent

Clinton Points Out Advances Notched in Mideast, Pakistan

clinton points out advances_Secretary of State Hillary Clinton, wrapping up a weeklong mission to Pakistan and the Middle East, shrugged off criticism of her diplomatic tactics and said she made important advances in her efforts to broker Arab-Israeli peace and promote stronger U.S. ties with the Islamic world.

Mrs. Clinton received qualified support Wednesday from Egypt’s leaders, who held three hours of talks in Cairo on the Mideast peace process with the top U.S. diplomat and her advisers.

Mrs. Clinton has been seeking Arab backing for a relaunching of direct Israel-Palestinian peace talks without the total freeze on Israeli settlement activity in the West Bank and East Jerusalem that President Barack Obama has repeatedly demanded.

The chief U.S. diplomat’s push has been rejected in recent days by many Arab leaders, as well as the Palestinian leadership, as a concession to Israel. But Egyptian President Hosni Mubarak’s government, a key player in Mideast politics, refrained from criticizing Mrs. Clinton’s plan and suggested there was a way forward for the negotiations.

“The United States and the secretary feel that there has been progress … about the issue of freezing the settlements, even if it’s not fully complete,” said Egyptian Foreign Minister Ahmed Aboul Gheit at a news briefing with Mrs. Clinton. “Here we feel that we need to focus on the endgame.”

Mr. Gheit blamed Israel for any failure in the talks. “We feel that Israel is hindering the process,” he said.

The Egyptian position helped Mrs. Clinton end a week of diplomacy on a relatively high note. Her trip was marked by public attacks on U.S. foreign policy and charges she backtracked on a key U.S. commitment to its Arab allies on the settlement issue.

Her public praise of Israeli Prime Minister Benjamin Netanyahu in Jerusalem on Saturday was widely seen as a diplomatic gaffe that undercut the Obama administration’s hopes of being seen as an honest broker between the Arabs and Israelis.

Mrs. Clinton’s swing through Pakistan, Israel and three key Arab states this week marked her most ambitious mission since taking office in January.

Some have seen the former first lady as a second-tier player within the Obama administration on Washington’s urgent foreign-policy challenges, particularly Iran, Afghanistan, and the Arab-Israeli conflict. Initially, Mrs. Clinton appeared to define her role as secretary by focusing on environmental, developmental and women’s issues.

Over recent days, Mrs. Clinton significantly shook up this perception.

In Islamabad, she met senior Pakistani generals and intelligence officials and pressed the U.S. fight against al Qaeda militants. In the Middle East, Mrs. Clinton stepped out of the shadow of the administration’s special envoy to the region, former Sen. George Mitchell, and pushed Israeli and Arab leaders to move toward peace.

The secretary and her advisers said they will continue pushing the Arabs and Israelis to return to peace talks — and also explore new mechanisms to better define the diplomatic path. By Jay Solomon, Wall Street Journal